Modeling Alzheimer’s Disease

Modeling Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by the neuropathological hallmarks of amyloid plaques and neurofibrillary tangles that eventually result in neuronal loss in the cerebral cortex and hippocampus. As functional human models, CDI’s neurons are actively being applied in research to investigate relevant molecular and cellular mechanisms of AD. These in vitro cellular models are capable of recapitulating the disease phenotype and have been employed in various assays including a high-throughput phenotypic screening assay resulting in the identification of candidate protective molecules.