Modeling Hepatitis Infection
Hepatitis infection mediated by HCV and HBV is a common cause of liver disease and failure. Developing effective therapies for hepatitis has been limited due to the lack of physiologically relevant human disease models. CDI’s hepatocytes express hepatitis receptors (SR-B1, CD91, occludin, claudin-1), which support uptake and replication of clinically relevant hepatitis virus genotypes. These hepatocytes are being used in large-scale screens for novel therapeutic candidates. CDI offers hepatocytes from multiple donors including one with an IFNL4 function that does not readily clear HCV infection.