Modeling Varicella Zoster Virus Infection

Modeling Varicella Zoster Virus Infection

CDI’s neurons provide a biologically relevant human cell model to study mechanisms of VZV infection, which was previously not possible using primary neuronal cells due to limitations in cell functionality and purity. Specifically, VZV infection results in a non-productive infection characterized by viral gene expression in the absence of apoptosis. This disease phenotype enables molecular analysis of VZV-neuron interactions and mechanisms of VZV reactivation.