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Modeling Parkinson’s Disease

Parkinson's disease is the result of a progressing degeneration of dopamine-producing brain cells, specifically midbrain dopaminergic neurons, that results in a loss of motor function and in dementia.

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Modeling Parkinson’s Disease

Discovery, Disease Modeling

Parkinson’s disease is the result of a progressing degeneration of dopamine-producing brain cells, specifically midbrain dopaminergic neurons, that result in a loss of motor function and in dementia. CDI’s neurons and dopaneurons are being used to elucidate the mechanisms that underlie the pathogenesis of Parkinson’s disease including mitochondrial dysfunction, synapse degeneration, ubiquitin-proteasome degradation, oxidative stress, and others.