Applications

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Monitoring Neurotoxicity

Measurements of cell health are a fundamental component of any disease research and drug development effort.

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Monitoring Neurotoxicity

Discovery, Toxicity

Measurements of cell health are a fundamental component of any disease research and drug development effort. Cell health endpoints represent various biological processes including cell morphology, viability, cytotoxicity, apoptosis, and mitochondrial integrity. In drug development, researchers interrogate these endpoints as part of discovery screening efforts and toxicity studies. CDI’s neurons, dopaneurons, and astrocytes have been utilized to measure various neural cell health endpoints using platforms including:

Measuring Neuronal Synaptic Activity

The measurement of neuronal synaptic activity can be accomplished through various signaling pathways.

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Measuring Neuronal Synaptic Activity

Discovery, Toxicity

The measurement of neuronal synaptic activity can be accomplished through various signaling pathways. These pathways can be measured in CDI’s neurons and dopaneurons using platforms including:

Measuring Neuronal Electrophysiology

The communication between neurons and between neurons and other cell types is accomplished through electrical signals.

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Measuring Neuronal Electrophysiology

Discovery, Regenerative Medicine, Toxicity

The communication between neurons and between neurons and other cell types is accomplished through electrical signals. CDI’s neurons exhibit biologically relevant electrical functions typical of primary human cortical neurons including evoked and spontaneous action potentials, inhibitory and excitatory post-synaptic currents, and ion channel pharmacology. These responses can be measured using platforms including:

Modeling Parkinson’s Disease

Parkinson's disease is the result of a progressing degeneration of dopamine-producing brain cells, specifically midbrain dopaminergic neurons, that results in a loss of motor function and in dementia.

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Modeling Parkinson’s Disease

Discovery, Disease Modeling

Parkinson’s disease is the result of a progressing degeneration of dopamine-producing brain cells, specifically midbrain dopaminergic neurons, that result in a loss of motor function and in dementia. CDI’s neurons and dopaneurons are being used to elucidate the mechanisms that underlie the pathogenesis of Parkinson’s disease including mitochondrial dysfunction, synapse degeneration, ubiquitin-proteasome degradation, oxidative stress, and others.