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CDI Notebook - June 2015
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Digital Media
iPSC-cardiomyocytes Webinar Registration

Accurate Prediction of On- and Off-target Cardiotoxicity with Human iPSC-derived Cardiomyocytes (Originally aired May 27). Hear about the practical implementation of iCell Cardiomyocytes in toxicity testing applications and how these cells could save resources, increase productivity, and result in safer medicines.


Botulinum Neurotoxin Protein Structure

Activity of Botulinum Neurotoxin Type D (Strain 1873) in Human Neurons. Read how researchers studied the mechanisms of a botulinum neurotoxin subtype, rarely known to cause botulism in humans, in iCell Neurons.

Pellet S, Tepp, WH, et al. (2015) Toxicon.



Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-derived Neurons. Discover how researchers characterized the functional properties of nAChRs expressed in iCell Neurons by means of calcium flux assays, performed at a single-cell level or by a higher throughput 96-well assay, as well as by patch-clamp electrophysiological technique.

Chatzidaki A, Fouillet A, et al. (2015) PLoS One.


Measuring Neuronal Cell Viability and Neurite Outgrowth

A Facile Method for Simultaneously Measuring Neuronal Cell Viability and Neurite Outgrowth. Learn about the development of a quick and simple fluorescent dye-based staining method for simultaneous measurement of cell health and relative neurite outgrowth from the same sample of iCell Neurons.

Hancock MK, Kopp L, et al. (2015) Curr Chem Gen & Transl Med.


Wanted: Your Presentation/Paper. Reward: Free Cells!
Upcoming Events
Mechanisms of Neurodegeneration

EMBO | EMBL Symposium: Mechanisms of Neurodegeneration (Jun 14 - 17 | Heidelberg, Germany). Join us at our exhibition and the following poster:

 Characterization of an Isogenic Disease Model of Alzheimer's Disease from Human iPS Cell-derived Neurons



ISSCR 2015 (Jun 24 - 27 | Stockholm, Sweden). Visit booth B06:11 and check out these posters:

 Assessing Functional Effects of a KCNT1 Mutation Associated with Epilepsy Using Human iPSC-derived Neurons (Poster W-1330)

 iPSC-derived Cardiomyocytes Produced from a Donor Carrying the MYH7-R403Q Exhibit Features of Hypertrophic Cardiomyopathy In Vitro (Poster T-1332)

 The Utility of Induced Pluripotent Stem Cell (iPSC)-derived Cardiomyocytes and Hepatocytes as an In Vitro Human Model System for High Content Screening of Complex Chemical Substances (Poster T-1287)


iCell Cardiomyocytes Application Protocol

Using Liposome-mediated Transfection for Gene Delivery. Learn how to deliver plasmid DNA into iCell Cardiomyocytes at high efficiency with low toxicity for assessment of gene or protein function.


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