Cellular Dynamics: We Develop Human Cells
CDI Notebook - September 2015
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CDI Notebook
Welcome to CDI Notebook
iForum 2015

Registration Is Still Open! iForum™ 2015 (Sep 14 - 16, Chicago | Oct 19, Hamburg). Make sure to attend the premier stem cell meeting. iPSC innovators are confirmed to discuss their research in the areas of disease modeling, discovery, toxicology, tissue engineering, and regenerative medicine.


Digital Media
CDI Website

CDI Website Offers Enhanced Content, Improved Searching Capability, and More. See our newly designed website that simplifies access to descriptions, methods, and references for iCell and MyCell products. Listings are filterable by cell or application type, and all application data are text searchable.


Botulinum Neurotoxin Protein Structure

Botulinum Neurotoxins Can Enter Cultured Neurons Independent of Synaptic Vesicle Recycling. Review data revealing that previous intoxication of neurons with botulinum toxins does not inhibit further uptake of the toxins.

Pellet S, Tepp WH, et al. (2015) PLoS ONE.



Development and Characterization of a Scaffold-free 3D Spheroid Model of iPSC-derived Human Cardiomyocytes. Evaluate the structural, functional, and predictive advantage of 3D versus 2D cardiac models through the work presented in this manuscript.

Beauchamp P, Moritz W, et al. (2015) Tissue Eng Part C Methods.



Improvement of Acquisition and Analysis Methods in Multi-electrode Array Experiments with iPS Cell-derived Cardiomyocytes. Understand how acquisition parameters affect data collection, data output, and interpretation in MEA-based investigations of cardiac proarrhythmia through the work of scientists associated with the Japanese Safety Pharmacology Society and the Japanese iPS Cardiac Safety Assessment.

Asakura K, Hayashi S, et al. (2015) J Pharmacol Toxicol Methods.



An Integrated Platform for Simultaneous Multi-well Field Potential Recording and Fura-2-based Calcium Transient Ratiometry in Human Induced Pluripotent Stem Cell (hiPSC)-derived Cardiomyocytes. Read how pharmaceutical researchers used an innovative technology for electrical activity measurement and intracellular handling to provide more granular and mechanistic data from drug-induced effects on cardiac toxicity.

Rast G, Weber J, et al. (2015) J Pharmacol and Toxicol Methods.


Botulinum Neurotoxin Protein Structure

A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-like Structure with Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized with Serotype A Antitoxin. Review how iPSC-derived neurons were used to help properly classify a novel botulinum toxin.

Maslanka SE, Luguez C, et al. (2015) J Infect Dis.


CDI in the News
CIRM & Coriell Institutes logos

CIRM Launches World's Largest Human Stem Cell Repository. Read about the recent release of 300 disease-specific stem cell lines with demographic and clinical data by the California Institute of Regenerative Medicine (CIRM). Researchers can obtain undifferentiated cells through the Coriell Institute and differentiated cells through CDI.


SeouLin Bioscience logo

CDI Names Korea Distributor. Welcome SeouLin Bioscience, who will distribute and support iCell products in the Republic of Korea. SeouLin is a leading biotech company and distributor of life science products with 30 years of industry experience.


Upcoming Events
MipTec 2015

MipTec Exhibition (Sep 22 - 24, Basel | Booth B45). Visit our booth to learn the latest CDI news and join us at the following talk:

 Implementing iPSC Technology: Case Studies on Deriving iPSCs from Clinical and Non-clinical Populations and Using iPSC-tissue Cells in Disease Modeling and Drug Discovery (Sep 23, 4:30 pm | Room 2)


SPS 2015

Safety Pharmacology Society Meeting (Sep 28 - Oct 1, Prague | Booth 35). Mark your SPS day planner to attend the following workshop in addition to stopping by our booth:

 Advancements in Human iPSC-derived Cardiomyocytes and MEA Technology Make for Robust, Higher Throughput Proarrhythmia Assessments with Less Cell Handling and Shorter Assay Times (Sep 30, 4:00 pm | Room Club E)



European Cardio Symposium (Oct 2, Prague). Hear about advances in drug discovery and toxicity testing using label-free impedance and MEA measurements on iCell Cardiomyocytes and iCell Cardiomyocytes2. Featured speakers include: Sarah Lamore, AstraZeneca; Hong Shi, Bristol-Myers Squibb; and Jason Maynes, The Hospital for Sick Children.


Botulinum Neurotoxin Protein Structure

Monitoring Insulin-dependent Glucose Uptake. Learn how iCell Skeletal Myoblasts aid diabetes research programs with relevant cellular pathways, HTP amenable procedures, and an approximately 2-fold increase in insulin-dependent glucose uptake.


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