Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on in vitro Cardiac Safety Evaluation.
See how researchers at Merck used iCell Cardiomyocytes to elucidate an increased beat rate phenomenon seen with Ca2+ channels blockers. The results are comparable to in vivo response & enhance predictivity for cardiac safety.
Zeng H, Wang J, Clouse H, Lagrutta A, and Sannajust F.
Toxicol Sci. 2018 Oct 26.