Cellular Dynamics
February 2019
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CDI
Welcome
Applications
Cellular Dynamics

See the Latest Procotol for iCell Microglia
Measuring Microglia Phagocytosis: Kinetic Imaging on the IncuCyte.
Neuronal homeostasis and synaptic pruning are supported by microglia through phagocytosis, a form of endocytosis. Using a combination of the IncuCyte S3 Live-Cell Analysis System and pHrodo BioParticles, the Application Protocol describes how to prepare iCell® Microglia, assay reagents, and compounds for measuring phagocytosis via kinetic imaging.

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Articles
Elsevier Brain Research

COA-Cl Induces Dopamine Release and Tyrosine Hydroxylase Phosphorylation: In Vivo Reverse Microdialysis and in Vitro Analysis

Discover how researchers at Kagawa University used iCell® DopaNeurons as an in vitro human model to characterize the neurotrophic effects of adenosine analog COA-Cl on regulating tyrosine hydroxylase activity and inducing neurite outgrowth.

Jamal, M., Tsukamoto, I., et al. (2019) Brain Research

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High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets.

Explore how researchers at the University of Virgina and AstraZeneca used iCell® Cardiomyocytes in a novel high content imaging assay to identify compounds that stimulate human cardiomyocyte proliferation, which may provide new therapeutic strategies for heart failure.

Woo, LA, Tkachenkoa S, et al. (2019) J. Mol. Cell. Cardiol.

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Upcoming Events
Cellular Dynamics

Society of Toxicology 2019 Annual Meeting
and ToxExpo

(Mar 10 - 14 | Baltimore MD | Booth 3115).

Mark your calendar now so you don't miss these talks and posters:

Sponsored Talk:
Monday, March 11 | 9:00 - 10:00 am | Room 340
hiPSC-CMs in Safety and Toxicity Testing—Diversity, Disease Modeling, and Resolving the Reversed Rate Effect of Calcium Channel Blockers

Presenter: FUJIFILM Cellular Dynamics, Inc.


Sponsored Talk:
Monday, March 11 | 12:00 - 1:00 pm | Room 338
The Utility of Electrical Field Stimulation for Functional Maturation of hiPSC-CM and Assessment of Inotropic Compounds

Presenter: ACEA Biosciences, Inc.

Poster Presentations:

Monday, March 11 | 9:15 am - 4:30 pm | Exhibit Hall
Abstract 1444 | Poster 513
Comparative Analysis of Human iPSC-Derived Cardiomyocytes in Diversity and Disease Modeling

Monday, March 11 | 9:15 am - 4:30 pm | Exhibit Hall
Abstract 1268 | Poster 297
Development of a High-Throughput iPSC-Derived Liver-on-a-Chip for Hepatotoxicity Detection

Thursday, March 14 | 8:30 - 11:15 am | Ballroom 1
Abstract 3282
Predicting Tyrosine Kinase Inhibitor Cardiotoxicity with a Biomarker-Based Human iPSC-Derived Cardiomyocyte Assay

SEE FCDI ACTIVITIES AT SOT >>

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