FUJIFILM Cellular Dynamics
March 2019
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Cellular Dynamics

CPVT Disease Model Cardiomyocytes

Now Available! iCell Cardiomyocytes CPVT (E2311D) RYR2 and Isogenic Control. Take advantage of the latest additions to our cardiac suite. These cardiomyocytes are perfectly suited for disease modeling studies aimed at understanding the physiological consequences of a mutation in the Cardiac Ryanodine Receptor (RyR2) resulting in Catecholaminergic Polymorphic Ventricular Tachycardia.

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Upcoming Events
Cellular Dynamics

SOT 2019 and ToxExpo

Mar 10 - 14 | Baltimore MD | Booth 3115
Attending SOT 2019? Mark your calendar now so you don't miss these presentations and posters

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Exhibitor-Hosted Sessions

Mon, Mar 11 | 9:00 - 10:00 am | CC Room 340

  hiPSC-CMs in Safety and Toxicity Testing—Diversity, Disease Modeling, and Resolving the Reversed Rate Effect of Calcium Channel Blockers

Mon 11 | 12:00 - 1:00 pm | CC Room 338

  The Utility of Electrical Field Stimulation for Functional Maturation of hiPSC-CM and Assessment of Inotropic Compounds

Tue, Mar 12 | 1:30 - 2:30 pm | CC Room 337

  Identify Functional and Structural Cardiotoxicants with the Biomarker-Based Cardio quickPredict Assay

Platform Session: Cardiovascular Toxicology & Hemodynamics

Thu, Mar 14 | 8:30 - 11:50 am | CC Ballroom I

  Predicting Tyrosine Kinase Inhibitor Cardiotoxicity with a Biomarker-Based Human iPSC-Derived Cardiomyocyte Assay

  Prediction of Liabilities with Chronic Drug Treatment in iPSC Derived Cardiomyocytes Using an MEA Platform

Poster Presentations

Mon, Mar 11 | 9:15 am - 4:30 pm | CC Exhibit Hall

  Abstract 1444: Comparative Analysis of Human iPSC-Derived Cardiomyocytes in Diversity and Disease Modeling

  Abstract 1268: Development of a High-Throughput iPSC-Derived Liver-on-a-Chip for Hepatotoxicity Detection

  Abstract 1323: Evaluating the Effects of the Muscarinic Receptor Agonist Pilocarpine on Neural Network Activity Using Three Cell Types on Different Days In Vitro on a Microelectrode Array Platform

Tue, Mar 12 | 9:15 am - 4:30 pm | CC Exhibit Hall

 Abstract 2049: The Multi-kinase Inhibitor, C374, Perturbs Excitation-Contraction Coupling in Human iPSC-Derived Cardiomyocytes

 Abstract 2052: Comparative Gene Expression Profiles of Human Ventricles and the Next Generation In Vitro Human Cardiac Model, Biowire II

 Abstract 2053: Simultaneous Impedance and Field Potential Measurements of hiPSC-Cardiomyocytes for Drug-Induced Cardiotoxicity Prediction

Thu, Mar 14 | 8:30 - 11:30 am | CC Hall A

 Abstract 3519: Distinct Carbon Sources Determine the Response of Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Hypoxia


Articles
Cellular Dynamics

Inhibitory Effects of Class 1 Antiarrhythmic Agents on Na+ and Ca2+ Currents of Human iPS Cell-derived Cardiomyocytes
Explore how researchers at Tottori University used iCell Cardiomyocytes to test responses to antiarrhythmic agents by studying elecrophysiological properties, mRNA levels of ion channel and Ca handling proteins, and Na+ and Ca2+ current responses.

Yonemizu, A., Masuda, K., et al. (2019) Regenerative Therapy

ARTICLE >>

Multi-dimensional in vitro Bioactivity Profiling for Grouping of Glycol Ethers
Read how researchers at Texas A&M University used iCell Cardiomyocytes and iCell Hepatocytes in the generation of high-content screening data for bioactivity profiling of solvents with a broad variation in toxicity.

Grimm, FA, House, JS, et al. (2019) Regulatory Toxicology and Pharmacology

ARTICLE >>


Engineered Botulinum Neurotoxin B with Improved Binding to Human Receptors Has Enhanced Efficacy in Preclinical Models
See how researchers at Ipsen Bioinnovation used iCell GABANeurons for testing the potency of a recombinant variant of BoNT/B1 that could potentially be used as an alternative to the popular BoNT/A1 that is used currently for treatments.

Elliot M, et al., (2019) Sciences Advances

ARTICLE >>

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling
See how researchers at TARA Biosystems and the University of Toronto used hiPSC-CMs to develop human heart models for preclinical risk assessment and disease modeling for drug discovery.


Zhao, Y, et al., (2019) Cell (2019)

ARTICLE >>

Human Models Are Needed for Studying Human Neurodevelopmental Disorders
Check out this great review on how human models are extremely relevant for neurodevelopmental research. FCDI offers neurons from several neurodevelopmental disorders, ready to use for your research!

Zhao, Y, and Bhattacharyya, A., (2018) American Journal of Human Genetics (2018)

ARTICLE >>

Applications
Cellular Dynamics

High-content Assay for Morphological Characterization of 3D Neuronal Networks in a Microfluidic Platform
Develop a high-throughput 3D neurite outgrowth assay using iPSC-derived neurons. 3D cultures are recognized as more closely recapitulating aspects of the human tissues including the architecture, cell organization, as well as cell-cell and cell-matrix interactions. In the application note, we optimize high-content imaging for evaluation of treatment effects on 3D neuronal networks and utilize 3D volumetric analysis to enable characterization of neuronal networks and provide quantitative measurements that can be used for defining EC50 values and comparing toxic effects of selected compounds.

APPLICATION NOTE >>

Cellular Dynamics

The iCell Microglia User's Guide
Now available, the full User's Guide for iCell Microglia. See the recommended protocols for preparing cell culture plates, thawing, plating and maintaining cells.

SEE THE USER'S GUIDE >>

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