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March 2019
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Microglia Disease Models

Now Available: iCell® Microglia Disease Models

We are now offering iCell Microglia isogenic disease models! Available models include triggering receptor expressed on myeloid cells 2 (TREM2), α-synuclein (SNCA, A53T) and methyl-CpG binding protein 2 (MeCP2) mutations. See a recently presented poster for characterization and functional data on these new isogenic microglia disease models.

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Nature Reviews Neurology - August 2019

Focus on Neuroinflammation

This month's issue of Nature Reviews Neurology is a collection of several reviews focused on neuroinflammation and its relationship to neurological disease. These reviews reinforce the relevance of our cryopreserved, assay-ready iCell Microglia disease models for TREM2, SNCA and MeCP2.

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Articles
Experimental Neurology 2019, Vol 316

Excess Glutamate Secreted from Astrocytes Drives Upregulation of P-glycoprotein in Endothelial Cells in Amyotrophic Lateral Sclerosis

Mohamed LA, Markandaiah SS, Bonanno S, Pasinelli P, and Trotti D. , Exp Neurol. 2019, 316:27-38

See a recent publication showing a model for blood-brain barrier targeting in ALS using iCell Astrocytes and Endothelial Cells.

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Nature Reviews Neurology - August 2019

An Epilepsy-associated KCNT1 Mutation Enhances Excitability of Human iPSC-derived Neurons by Increasing Slack KNa

Quraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, and Kaczmarek LK, Journal of Neurosci., 26 July 2019, 1628-18.

See how professors Fred H. Gage and Leonard K. Kaczmarek used our iCell GABANeurons harboring KCNT1 mutation to model epilepsy.

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Upcoming Events
Cellular Dynamics

Safety Pharmacology Society 2019 Annual Meeting

Come visit FCDI at Booth 406 and see the latest iPSC-derived tools for safety assessment and disease modeling. We will also be presenting a poster entitled
Integrated Analysis of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Diversity and Disease Modeling

SEE MEETING DETAILS & POSTER ABSTRACT >>

Cellular Dynamics

23rd Annual Merck Symposium

This year’s 23rd Annual Merck Technology Symposium provides a networking forum for nearly 1000 Merck scientists, with talks and posters, supplemented by a supplier trade show with over 70 exhibitors. The meeting will be organized around several tracks illustrating the various ways that technologies are facilitating scientific decision-making at Merck

MEETING DETAILS >>

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