Ion channels are an important class of therapeutic drug targets, and mutations in ion channel genes are found to be responsible for an increasing number of diseases. While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput. Because of this, ion channels remain an underrepresented target class for drug discovery. But the advent of automated electrophysiological systems with higher throughput has begun to revolutionize ion channel drug discovery. This symposium focuses on the emerging technology of automated electrophysiology and how it is changing the face of ion channel drug discovery. Speakers from industry and academia will discuss the development and potential of these new technologies, present experimental results obtained using these systems and discuss the impact these technologies are having on ion channel drug discovery.
One of the featured talks will describe the application of MyCell Neurons containing a KCNT1 mutation in the investigation of potassium channel function:
1:30 PM – 2:00 PM
Investigation of Potassium Channel Function Utilizing Human iPSC-derived Neurons
Matthew Fuller, Icagen Inc.