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Modeling Chemotherapy-induced Peripheral Neuropathy with Stem Cell Technology

July 8, 2014

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Abstract

With over 28 million cancer survivors worldwide, awareness of long-term toxicities and impact on quality of life in cancer survivors has heightened. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and potentially permanent side effects of modern chemotherapy. The mechanisms underlying CIPN have not been precisely determined, and few human neuronal models to study CIPN exist.

This talk highlights:

  • The use of human iPSC-derived neurons as a model to study the effects of chemotherapy on neuronal health
  • In vitro assays used to assess chemotherapy-induced morphological changes of the neurons and genes involved in CIPN
  • The potential use of human iPSC-derived neurons for high-throughput drug-induced neurotoxicity screening