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SLAS 2018

February 3 - February 7

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SLAS2018 is the annual flagship International Conference and Exhibition from SLAS. Through a unique combination of education, access to innovative technologies and intelligent peer networking, SLAS2018 delivers unmatched value for professionals and students looking to discover the latest life sciences technologies and how they can be applied to drive research objectives.

Cellular Dynamics Exhibitor Tutorial

Predictive Screening with iPSC-derived Cardiomyocytes and Neurons on High-speed/High-throughput Calcium Imaging

Monday, February 5 | 2:00 PM – 2:45 PM | Room 1A

Speakers: Beatriz Freitas, Field Application Scientist, Cellular Dynamics International – a Fujifilm Company, and Natsumi Kato, Application Engineer, Hamamatsu Phototonics K.K.

Human iPSC technology and the Hamamatsu FDSS/µCELL screening platform bring relevant biology and predictive data acquisition to early drug discovery and toxicity screening efforts. Human cell types differentiated from induced pluripotent stem cells (iPSC) recapitulate normal and patho-physiological native cellular behavior while the FDSS/µCELL platform enables phenotypic and mechanistic investigation at high throughput rates. This presentation highlights recent advances demonstrating:
(1) Refining Calcium Response using iPSC-derived Models – iCell Cardiomyocytes & iCell DopaNeurons: Shows the ability for discovery-based screening in neurons and cardiomyocytes across several induced and patient-derived disease phenotypes (Parkinson’s, cardiac hypertrophy, etc.)
(2) Overview of FDSS for Ca2+/Membrane Potential Signal Measurement in Human iPSC-derived Cardiomyocytes & Neurons: Describes prediction and mechanistic resolution of proarrhythmia and drug-drug interactions for toxicity and safety pharmacology assessments.

These case studies demonstrate the ease of predictive screening with iPSC-derived tissue cells and Ca2+ imaging from Cellular Dynamics International and Hamamatsu, respectively, while illustrating the value of using human material and functional readouts for early and accurate answers.

CDI-related Poster Presentations

1311-B | Mon, Feb 5, 5:00 – 6:00 pm
Fluorescence Measurement of Ca2+ Transients in Human iPSC­-derived Cardiomyocytes for Assessment of Drug-induced Proarrhythmia: Automatic Detection of EAD-like Waveforms
Presenter: Natsumi Kato, Hamamatsu Photonics K.K., Hamamatsu, Japan

1292-C | Tue, Feb 6 | 2:00 – 3:00 pm
Development of a Kinetic Plate Reader for Cardiotoxicity Screening Using Human iPSC-derived Cardiomyocytes and Ca2+ Transients Measurement
Presenter: Natsumi Kato, Hamamatsu Photonics K.K., Hamamatsu, Japan

 

Details

Start:
February 3
End:
February 7
Website:
https://www.slas2018.org/

Organizer

SLAS
Website:
https://www.slas.org/

Venue

San Diego Convention Center
111 W Harbor Dr
San Diego, CA