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SOT18 & ToxExpo

March 11 - March 15

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Every March, around 6,500 toxicologists and 350 exhibitors attend the SOT Annual Meeting and ToxExpo, the largest gathering of industry, governmental, and academic toxicologists in the world.

Join Cellular Dynamics for an Exhibitor-Hosted Session

Monday, Mar 12 | 12:00 – 1:00 pm | Room 217A

Neurotox and Cardiac Safety Assessment: Case Studies Employing iPS Cell Lines and Next-Generation MEA Technology

Presented By: Axion BioSystems and Cellular Dynamics International, a FUJIFILM company

Discover the predictive power of iCell® Cardiomyocytes2 and iCell GlutaNeurons with the Maestro Pro multiwell MEA platform.  Experts in the field will present case studies on optimization of neuronal/astrocyte co-culture for neurotoxicology (HESI NeuTox) and incorporation of the local extracellular action potential (LEAP) signal for cardiac safety (CiPA).


Posters & Presentations at SOT18

Monday, Mar 12

Poster Presentations 10:45 am – 12:15 pm | Exhibit Hall

Abstract 1138 | Poster 178
Use of a Chronic Multiplatform Assay to Evaluate Cardiotoxicity of BMS-986094 in iPSC-derived Human Cardiomyocytes
Author: Cyprotex

Abstract 1139 | Poster 179
Development of an In Vitro Assay to Predict Cardiotoxicity Potential Using Targeted Metabolomics and Human-induced Pluripotent Stem Cell-derived Cardiomyocytes
Authors: Stemina Biomarker Discovery and UCB Biopharma SPRL

Abstract 1144 | Poster 184
A Cell Model to Evaluate Chemical Effects on Adult Human Cardiac Progenitor Cell Differentiation and Function
Author: US Environmental Protection Agency

Abstract 1145 | Poster 185
Biowire II-matured Human-engineered Cardiac Tissues Have Adult-like Responses to Inotropic Agents
Authors: TARA Biosystems and GlaxoSmithKline

Abstract 1149 | Poster 189
Adult Human Stem Cell-derived Cardiomyocytes: An Alternative Model for Evaluating Chemical and Environmental Pollutant Cardiotoxicity
Authors: US Environmental Protection Agency

Poster Presentations  | 1:30 – 3:00 pm | Exhibit Hall
Abstract 1572 | Poster 803
Optogenetic Pacing for Assessment of Proarrhythmic Potential of Drugs in Induced Pluripotent Stem Cell-derived Cardiomyocytes
Author: US Food and Drug Administration

Abstract 1595 | Poster 826
Use of Stem Cell-derived Cardiomyocytes to Detect Cardiac Proarrhythmic Liabilities: Defining the Limits
Author: Charles River


Tuesday, Mar 13

Exhibitor-hosted Session 1:30 – 2:30 pm | CC Rm 217A
Cardio QuickPredict: A New Way to Evaluate the Cardiotoxicity Potential of Compounds
Host: Stemina Biomarker Discovery

Poster Presentations 1:30 – 3:00 pm | Exhibit Hall
Abstract 2328 | Poster 675
Comparison of Different Sources of Stem Cell-derived Hepatocyte-like Cells with Respect to Hepatocyte Functionality
Authors: Bayer AG and Institute for Stem Cell Research and Regenerative Medicine

Abstract 2338 | Poster 685
Multiparametric Assessment of Networked Electrical Activity Using Induced Pluripotent Stem Cell-derived Glutamatergic Neurons
Author: Cellular Dynamics

Abstract 2342 | Poster 689
Optimization of Optogenetic Transduction of Stem Cell-Derived Cardiomyocytes with Adeno-Associated Virus for Optically Paced Cardiac Electrophysiology Assays
Author: Axion Biosystems

Abstract 2345 | Poster 692
Comparison of the Proarrhythmia Liability of Standard and Functionally Mature Human iPSC-derived Cardiomyocytes
Author: ACEA Biosciences

Abstract 2350 | Poster 704
Human-derived Cardiomyocytes for Testing Cardiotoxicity of Industrial Chemicals of Concern
Author: US Army Public Health Center

Abstract 2351 | Poster 705
Cardiovascular Toxicity Screening of Polychlorinated Biphenyls and Their Major Metabolites
Author: Grimm et al., Texas A&M


Wednesday, Mar 14

Workshop Session 8:05 am – 10:45 am | Hemisfair Ballroom C2
Cardiovascular Adverse Effects Are Still Causing Late Attrition of Novel Therapeutics: Developing Solutions to Detect and Avoid Cardiovascular Toxicity in the Clinic – Use of hiPSC-derived Cardiomyocytes for Cardiac Safety Evaluation
Speaker: L. Gu, Frederick National Laboratory for Cancer Research

Poster Presentation |  10:45 am – 12:15 pm | Exhibit Hall
Abstract 2354 | Poster 691
Characterization of the Local Extracellular Action Potential Signal for Use in Cardiac Safety Evaluation
Author: Axion Biosystems

Abstract 3026 | Poster 581
Human Induced Pluripotent Stem Cell Models for In Vitro Neurotoxicity Testing
Author: Tukker et al., Utrecht University


Thursday, Mar 15

Poster Presentations | 8:30 – 11:30 am | Exhibit Hall
Abstract 3606 | Poster 399
Inhibition of Iĸr and Iĸs Repolarizing Potassium Currents and Repolarization Reserve in Human iPSC Cardiomyocytes
Author: Bristol-Myers Squibb

Abstract 3325 | Poster 106
In Vitro Approaches to Grouping of Complex Substances and UVCBs: A Case Study of Olefin Streams
Author: Grimm et al., Texas A&M

Abstract 3331 | Poster 112
In Vitro Toxicity Testing: To CMax or Not To CMax?
Author: US Food and Drug Administration – National Center for Toxicological Research

Details

Start:
March 11
End:
March 15
Website:
https://www.toxicology.org/events/am/AM2018/index.asp

Organizer

Society of Toxicology
Website:
https://www.toxicology.org/

Venue

Henry B. Gonzalez Convention Center
900 E Market St.
San Antonio, TX 78205 United States
Website:
http://www.sahbgcc.com/