Reprogramming technology has opened up a new frontier for disease modeling using patient-derived induced pluripotent stem cells (iPSCs). While the prospects of gaining insight into disease mechanisms using human cells seem promising, and identifying potential treatments merely a high throughput screen away, modeling disease in a dish presents its own set of challenges. In addition to validating a meaningful in vitro disease phenotype, modeling complex disease, where the pathogenesis is believed to result from interactions between genes and environmental factors, is particularly challenging. In the forthcoming Cell Press webinar “Using stem cells to Model Disease” on September 19th, Lawrence Goldstein, Kristen Brennand and Lorenz Studer will tell us about the strategies they used to overcome some of these challenges.Hear how they approach modeling of Alzheimer’s disease, Schizophrenia and Neurodegenerative disorders using patient-derived iPSCs, and to learn how these approaches could be applicable to modeling complex diseases.
- This event has passed.