Drug discovery strategies include target-based molecular approaches and phenotypic-based empirical approaches. Our recent analysis revealed the phenotypic approach as the more successful strategy for first-in-class medicines. We rationalized that this success was influenced by the unbiased identification of a molecular mechanism of action (MMOA) that contributed to a useful therapeutic index. The value and success of phenotypic approaches will be further increased through efforts to bridge the gap between molecular and phenotypic approaches. In this webinar I will discuss challenges and solutions to assimilating molecular and phenotypic approaches to increase drug discovery success.
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