Enhancing the Functional Maturity of iPSC-derived Human Hepatocytes via Controlled Presentation of Cell-Cell Interactions In Vitro. Discover how an engineered co-culture platform increased the maturation and longevity of iCell Hepatocytes when benchmarked against primary human hepatocytes. iCell Hepatocytes demonstrated increased maturity via global gene expression profiles, hepatic polarity, secretion of albumin and urea, basal CYP450 activities, phase-II conjugation, drug-mediated CYP450 induction, and drug-induced hepatotoxicity further enhancing their utility in compound screening.
Berger DR, Ware BR, et al. (2014) Hepatology.
Human Induced Pluripotent Stem Cell-derived Hepatocytes for Toxicology Testing. Read how combining iCell Hepatocytes with organotypic culture systems enables researchers to maximize the potential of these technologies. iCell Hepatocytes benefit from the complex culture conditions while providing stability and reproducibility to the use of organotypic cultures in drug research.
Mann DA (2014) Expert Opin Drug Metab Toxicol.
Human Stem Cell-derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line. Read this review for an update on measuring cellular impedance and how it may be applied to detect multiple toxicity modalities and implemented into a cascading screening paradigm to detect cardiotoxicity.
Peters M, Lamore SD, et al. (2014) Cardiovasc Toxicol.
A Multi-parameter In Vitro Screen in Human Stem Cell-derived Cardiomyocytes Identifies Ponatinib-induced Structural and Functional Cardiac Toxicity. Find out how scientists moved beyond single end-point assays and combined a suite of biochemical, structural, and functional assays to identify and characterize the cardiotoxicity caused by ponatinib, a multi-targeted tyrosine-kinase and pan-ABL inhibitor.
Talbert DR, Doherty KR, et al. (2014) Tox Sci.
Optimization and Critical Evaluation of Decellularization Strategies to Develop Renal Extracellular Matrix Scaffolds as Biological Templates for Organ Engineering and Transplantation. Learn how researchers utilized iCell Endothelial Cells in biomatrices and decellularized organ scaffolds that may ultimately serve as a model for kidney bioengineering.
Caralt M, Uzarski JS, et al. (2014) Am J Transplant.