News & Events

January 2013

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JANUARY 2013

Welcome to the inaugural issue of our monthly enewsletter, CDI Notebook, which will keep you abreast of the latest innovations using CDI’s iPS cell technology.

In this issue:
Upcoming Events
iCell Application Notes & Protocols
Published Research

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Upcoming Events

SLAS2013 (Jan 12 – 16, 2013). Several SLAS2013 events highlight CDI’s iPS cell technology, including a podium presentation, three posters, and three industry symposia. In addition, CDI is co-hosting a customer event with appetizers and beverages especially for SLAS attendees.

iCell® Cardiomyocytes iCertification Training Program (Feb 13 – 14, 2013). This 2-day course provides advanced training on handling and applications of iCell Cardiomyocytes in a
variety of assays and analytical platforms. Upon completion, the skills and knowledge acquired enable successful adoption of iCell Cardiomyocytes for your experimental research. Details>>

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iCell Application Notes & Protocols

iCell Products – Applying Transfection Technologies to Create Novel Screening Models. This application note provides methodology and data detailing how iCell Cardiomyocytes, iCell Neurons, and iCell Endothelial Cells are compatible with several commercially available transfection reagents. Download>>

iCell Neurons – Multielectrode Array System. This application protocol provides instructions on thawing and culturing iCell Neurons directly on MEA chips to form neuronal networks amenable to electrophysiological interrogation using a multielectrode array system. Download>>

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Published Research

The Effects of Jaspamide on Human Cardiomyocyte Function and Cardiac Ion Channel Activity. Use of iCell Cardiomyocytes to demonstrate that the acute in vivo toxicity of jaspamide, an anti-neoplastic agent, were due to toxic effects on cardiomyocytes.
Schweikart K, Guo L, Shuler Z, Abrams R, Chiao ET, Kolaja KL, Davis M. (2012) Toxicol In Vitro. Published online ahead of print. Article>>

Prevention of β-amyloid Induced Toxicity in Human iPS Cell-derived Neurons by Inhibition of Cyclin-dependent Kinases and Associated Cell Cycle Events. First known use of human iPS cell-derived neurons (iCell Neurons) to model Alzheimer’s disease through β-amyloid toxicity, showing potential for use in high throughput drug screening.
Xu X, Lei Y, Luo J, Wang J, Zhang S, Yang X, Sun M, Nuwaysir E, Fan G, Zhao J, Lei L, Zhong Z. (2012) Stem Cell Res. Published online ahead of print. Article>>

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