News & Events

May 2013


MAY 2013

Welcome to our monthly enewsletter, CDI Notebook, focused
on keeping you abreast of the latest innovations using CDI’s
iCell® and MyCell® products.

In this issue:
Application Notes & Protocols
Conference News

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Human iPSC-derived Hepatocytes: Functional Model Tissue for In Vitro Predictive Metabolism, Toxicity, and Disease Modeling. Entails iCell Hepatocytes’ predictivity for hepatotoxicity and disease modeling, including hepatitis C infection.

Mann DA, Einhorn S, Block K, Fuhrken P, Kannemeier C,
Luebke-Wheeler J. (2013) GEN (33) 9.


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Advancements in the Use of iPS Cell-derived Systems for In Vitro Disease Modeling
and Phenotypic Screening.
Details a variety of assays showing the utility of iCell technology in
drug development and discovery, disease modeling, and compound screening.



Development and Characterization of Human Induced Pluripotent Stem Cell-derived Model Systems for Muscular Dystrophy Disease Modeling and Drug Development Scientific Conference. Demonstrates how iCell products supply clinically relevant cellular models for muscular dystrophy disease research and drug testing.

Presented at MDA Scientific Conference 2013



Synthetic Extracellular Matrix for Investigating 3D Vascular Network Formation. Shows the application of iCell Endothelial Cells in investigating vascular network formation on synthetic extracellular matrices.

Presented at Society for Biomaterials 2013


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Application Notes & Protocols


Silencing Gene Expression: siRNA Delivery by Transfection. Provides a detailed protocol for performing siRNA delivery by transfection for efficient gene silencing of GAPDH in iCell Neurons. It serves as a guide for delivery of other siRNAs for use in different plate formats and endpoint readouts.


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Conference News


iCell Workshop. Register now for a multi-session iCell workshop on May 20, 2013, in London, UK:

Advances in Human iPSC-derived Cell Models
for Phenotypic Screening & Toxicity Studies

Speakers from pharma and academia will discuss how iCell products are advancing their research:

  • Devyn Smith, PhD, Pfizer Neusentis
  • Kate Harris, PhD, GlaxoSmithKline
  • Daniel Ursu, PhD, Eli Lilly
  • Mei Ding, PhD, AstraZeneca
  • Sian Harding, PhD, Imperial College

Workshop Details>>

Upcoming Conferences. The following conferences include talks highlighting the utility of iCell technology in life science research and drug development:

  • Advances in In Vitro Cell & Tissue Culture, May 21 – 22, Liverpool, UK:Induced Pluripotent Stem Cell-derived Model Systems: Applications for Predictive
    and Mechanistic Toxicology In Vitro
  • World Stem Cell & Regenerative Medicine, May 21 – 23, London, UK:Moving Drug Therapy Forward: Case Studies Using Human iPS Cell-based Models
  • NIH FAES Stem Cell Industry Symposium, May 29, Bethesda, MD:Application of Human iPS Cell-derived Cellular Models for Disease Modeling, Drug Discovery, and Toxicity Testing
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