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Non-invasive Video Analysis of Beating Cardiomyocytes

cellogyA recent study using iCell® Cardiomyocytes demonstrated the use of non-invasive video analysis to measure the biomechanical contraction and relaxation of cardiomyocytes.1

This video analysis technology, Pulse (Cellogy, Inc.), uses video microscopy and advanced image analysis algorithms2 to measure various beating parameters (Figure 1) without any labels or contact with cells. When used with iCell Cardiomyocytes, Pulse enables fast, accurate measurement of drug-induced changes in beating patterns, including GPCR effects and detection of arrhythmias (Figure 2).

Contact CDI’s Technical Support and visit the Cellogy website for further information on using Pulse with iCell Cardiomyocytes.

Figure 1

Figure 1: Non-invasive Measurement of Cardiomyocyte Beating Using Video Analysis

 

Figure 2

Figure 2: Video Analysis Successfully Captured Drug Effect on Beating Signals of iCell Cardiomyocytes

References

  1. Maddah M, Heidmann J, et al. A Non-invasive Platform for Functional Characterization of Stem-cell-derived Cardiomyocytes with Applications in Cardiotoxicity Testing. Stem Cell Reports 4(4):621-631.
  2. Maddah M and Loewke K (2014) Non-invasive Characterization of Stem Cell-derived Cardiomyocytes from Phase-Contrast Microscopy. Proceedings of Medical Image Computing and Computer Assisted Intervention (MICCAI).