News & Events

November 2014

Share: Share Using Facebook  Share Using Twitter
CDI Notebook

NOVEMBER 2014

bogo_padded

Welcome to our monthly enewsletter, CDI Notebook, focused on keeping you abreast of the latest innovations using CDI’s iCell® and MyCell® products.

In this issue:
Trending
Webinars
Publications
Conference News
Applications
Presentations/Posters
Press

enewsletter_hr-big

Trending

cipa_logo

CDI has shipped iCell Cardiomyocytes for the CIPA project, and studies are underway. Learn the latest developments in the CIPA initiative by participating in the workshop, Rechanneling the Current Cardiac Paradigm: Arrhythmia Risk Assessment during Drug Development without the Thorough QT Study (Dec 11 | Silver Spring, MD).

Workshop>>

enewsletter_hr-big

Webinars

Drug-induced Organ Injury Series: Proarrhythmia (Nov 19). Hear concepts for non-clinical assessment of proarrhythmic risk and approaches to clinical assessment of risk. Chairperson: Dr. Norman Stockbridge, FDA. Presenters: Dr. David Strauss, FDA; Dr. Gary Gintant, Abbvie; Dr. Borje C. Darpo, iCardiac Technologies; Dr. Blake Anson, Cellular Dynamics

Register>>

Efficiently Build Relevant In Vitro Models Using Human Stem Cell-derived Tissue Cells, High Performance Transfection and Novel Multiplexed Reporter Techniques (Dec 9). Find out how to use highly pure human tissue cells and new transfection techniques to build relevant cell models that recapitulate disease phenotypes and enable rapid, quantitative analysis of biological pathways. Presenters: Dr. Matthew Robers, Promega; Dr. Brian Jarecki, Cellular Dynamics

Register>>

“First in Human” – The Potential of Neural Stem Cell-based Approaches for Treatment of Brain Disorders (Dec 16). Learn how pluripotent stem cell technologies overcome the hurdles in translational neuroscience to model “human” neural disease pathology and serve as platforms for drug development. Presenters: Dr. Ricardo Dolmetsch, Stanford University; Dr. Kevin Eggan, Harvard University; Dr. Fred H. Gage, Salk Institute

Register>>

enewsletter_hr-big

Publications

Assessment of Testing Methods for Drug-induced Repolarization Delay and Arrhythmias in an iPS Cell-derived Cardiomyocyte Sheet: Multi-site Validation Study. Find out how the function and responsiveness of iCell Cardiomyocytes to drug-induced effects was found to be highly reproducible across multiple sites and investigators.

Nakamura Y, Matsuo J, et al. (2013) J Pharmacol Sci.

Article>>

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy Using Human Induced Pluripotent Stem Cells. Learn how scientists induced diabetic cardiomyopathy models via environmental and genetic drivers in iCell Cardiomyocytes and MyCell donor-specific iPSC-derived cardiomyocytes, respectively. Small molecule screens identified molecules and pathways that may provide therapeutic relevance in concordance with the clinical phenotype.

Drawnel FM, Boccardo S, et al. (2014) Cell Reports.

Article>>

Human Stem Cell-derived Cardiomyocytes Detect Drug-mediated Changes in Action Potentials and Ion Currents. Discover how researchers validated the mechanistic effects of a drug block on iCell Cardiomyocytes using single-cell patch clamp technology.

Gibson JK, Yue Y, et al. (2014) J Pharmacol Toxicol Methods.

Article>>

Image-based Evaluation of Contraction–Relaxation Kinetics of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes: Correlation and Complementarity with Extracellular Electrophysiology. Read about a label-free, image-based technique to assess the contractility of iCell Cardiomyocytes. This novel method was validated against traditional traction-force microscopy, electrophysiological, and calcium signaling methodologies.

Hayakawa T, Kunihiro T, et al. (2014) J Mol Cell Cardiol.

Article>>

An Impedance-based Cellular Assay Using Human iPSC-derived Cardiomyocytes to Quantify Modulators of Cardiac Contractility. See how a surrogate screening platform employing iCell Cardiomyocytes and impedance-based technology provided a higher throughput system to identify changes in contractile activity with comparable endpoints to the lower throughput gold standard method.

Scott CW, Zhang X, et al. (2014) Toxicol Sci.

Article>>

Molecular Mechanisms of Alzheimer’s Disease Protection by the A673T Allele of the Amyloid Precursor Protein. Find out how researchers used MyCell Neurons to investigate the impact of SNPs in the amyloid precursor protein as it relates to Alzheimer’s disease progression.

Maloney JA, Bainbridge T, et al. (2014) J Biol Chem.

Article>>

enewsletter_hr-big

Conference News

Neuroscience 2014 (Nov 15 – 19 | Washington DC | Booth 436). Mark your day planner now so you don’t miss these posters:

  • Characterization of an Isogenic Disease Model of Alzheimer’s Disease from Human iPS Cell-derived Neurons (Nov 16 | 8:00 am – 12:00 pm | Poster D70)
  • A New MEA Analysis Tool for Measuring Pharmaco-influences on Human iPS Cell-derived Neurons (Nov 17 | 8:00 am – 12:00 pm | Poster VV20)
  • Axonal Polarity Formation in Human iPSC-derived Neurons (Nov 17 | 1:00 – 5:00 pm | Poster B18)
  • Development and Characterization of Scalable Human Induced Pluripotent Stem Cell-derived Midbrain Dopaminergic Neurons for Drug Discovery and Disease Modeling (Nov 17 | 1:00 – 5:00 pm | Poster B11)
  • Human Neural Microtissues Derived from Induced Pluripotent Stem Cells for Toxicity Testing (Nov 19 | 8:00 am – 12:00 pm | Poster VV69)
  • Model of Tau Pathology in Induced Pluripotent Stem Cell-derived Human Neurons (Nov 19 | 1:00 – 5:00 pm | Poster C67)
  • Computational Analysis of the Effects of Anti-neoplastic Agents on Intraneuronal Transport of Human iPSC Derived Neurons (Nov 19 | 1:00 – 5:00 pm | Poster VV24)

FAST Congress: Organotypic Culture Models for Toxicology (Nov 17 – 19 | Boston, MA). Join us at the following talk:

  • Human iPSC-derived Tissues in Complex Organotypic Culture Systems for Predictive Toxicity Assessment (Nov 17 | 2:05 pm)

Details>>

enewsletter_hr-big

Applications

application

Pacing iCell Cardiomyocytes. Discover how AxIS 2.0 Software (Axion BioSystems) enables researchers to pace cardiomyocytes for more granular electrophysiological investigations.

Details>>

enewsletter_hr-big

Presentations/Posters

Check out these iCell Cardiomyocytes presentations and posters, presented at recent meetings, now accessible online:

    • presentationCardiotoxicity, QT Prolongation, and Arrhythmia Prediction Using iCell Cardiomyocytes: Past, Present and Future (ACEA Biosciences: xCELLigence Cardio Symposium)

Presentation>>

    • New Techniques for MEA-based Interrogation of Human Stem Cell Derived Cardiomyocytes to Support CiPA and In-vitro Safety Pharmacology Assays (SPS Meeting)

Presentation>>

    • We’ve crossed the Chasm and Climbed out of the Trough: Advances and Advantages with iPSC-derived Cell Types in Drug Discovery (ChanTest User Meeting)

Presentation>>

    • Cardiac Safety Profile of Pan-HER Inhibitors Afatinib and Neratinib Using a Multi-parameter In Vitro Screening Approach (SPS Meeting)

Poster>>

    • Determination of Pro-arrhythmic Effects of Compounds in Human iPSC-derived Cardiomyocytes Using FDSS/µCell Imaging Platform (SPS Meeting)

Poster>>

    • Evaluation of Nifedipine on Action Potentials, Ion Currents, and Calcium Transients from Adult Human Stem Cell-derived Cardiomyocytes (SPS Meeting)

Poster>>

    • Rapid Intensity Modulation of a Single Light Source Allows Excitation of Voltage Sensitive Dye and Intermittent Activation of Channel Rhodopsin in hiPSC Derived Cardiomyocytes (hiPSC-CMs) (SPS Meeting)

Poster>>

    • The Use of iCell Cardiomyocytes with Cell-by-Cell Calcium Analysis Reveals Compound Induced Changes in Cardiac Repolarization and Generation of Pro-arrhythmia Signals (SPS Meeting)

Poster>>

enewsletter_hr-big

Press

Cellular Dynamics International Awarded National Eye Institute Contract. Read about the award from the National Eye Institute for Cellular Dynamics to develop and manufacture autologous human retinal pigment epithelial cells for the potential treatment of macular degeneration.

Milwaukee Journal Sentinel Article>> | Cellular Dynamics Press Release>>

enewsletter_hr-big
© 2014 Cellular Dynamics International, Inc.
525 Science Drive, Madison, WI 53711
+1 (608) 310-5100 or toll-free (877) 310-6688
www.cellulardynamics.com
Follow us: CDI on Facebook CDI on LinkedIn CDI on Twitter CDI on YouTube