Assessment of Testing Methods for Drug-induced Repolarization Delay and Arrhythmias in an iPS Cell-derived Cardiomyocyte Sheet: Multi-site Validation Study. Find out how the function and responsiveness of iCell Cardiomyocytes to drug-induced effects was found to be highly reproducible across multiple sites and investigators.
Nakamura Y, Matsuo J, et al. (2013) J Pharmacol Sci.
Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy Using Human Induced Pluripotent Stem Cells. Learn how scientists induced diabetic cardiomyopathy models via environmental and genetic drivers in iCell Cardiomyocytes and MyCell donor-specific iPSC-derived cardiomyocytes, respectively. Small molecule screens identified molecules and pathways that may provide therapeutic relevance in concordance with the clinical phenotype.
Drawnel FM, Boccardo S, et al. (2014) Cell Reports.
Human Stem Cell-derived Cardiomyocytes Detect Drug-mediated Changes in Action Potentials and Ion Currents. Discover how researchers validated the mechanistic effects of a drug block on iCell Cardiomyocytes using single-cell patch clamp technology.
Gibson JK, Yue Y, et al. (2014) J Pharmacol Toxicol Methods.
Image-based Evaluation of Contraction–Relaxation Kinetics of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes: Correlation and Complementarity with Extracellular Electrophysiology. Read about a label-free, image-based technique to assess the contractility of iCell Cardiomyocytes. This novel method was validated against traditional traction-force microscopy, electrophysiological, and calcium signaling methodologies.
Hayakawa T, Kunihiro T, et al. (2014) J Mol Cell Cardiol.
An Impedance-based Cellular Assay Using Human iPSC-derived Cardiomyocytes to Quantify Modulators of Cardiac Contractility. See how a surrogate screening platform employing iCell Cardiomyocytes and impedance-based technology provided a higher throughput system to identify changes in contractile activity with comparable endpoints to the lower throughput gold standard method.
Scott CW, Zhang X, et al. (2014) Toxicol Sci.
Molecular Mechanisms of Alzheimer’s Disease Protection by the A673T Allele of the Amyloid Precursor Protein. Find out how researchers used MyCell Neurons to investigate the impact of SNPs in the amyloid precursor protein as it relates to Alzheimer’s disease progression.
Maloney JA, Bainbridge T, et al. (2014) J Biol Chem.