News & Events

October 2014

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CDI Notebook

OCTOBER 2014

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Welcome to our monthly enewsletter, CDI Notebook, focused on keeping you abreast of the latest innovations using CDI’s iCell® and MyCell® products.

In this issue:
Trending
Webinars
Publications
Conference News
Applications
Presentations/Posters

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Trending

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Cellular Dynamics and the CIPA Initiative. Learn about the Comprehensive In Vitro Proarrhythmia Assay (CIPA) project, an international initiative with the primary goal of creating a more predictive biomarker for drug-induced cardiac arrhythmia. CIPA initiative members include the US Food and Drug Administration, European Medicines Agency, Health Canada, Japan National Institute of Health Sciences, and others. Cellular Dynamics is providing scientific input as well as supplying iCell Cardiomyocytes for this project.

Details>>

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Webinars

Use of iPSC as Screening Tools and Therapeutics (Originally aired Sep 11). Find out the preclinical and manufacturing regulatory issues in moving iPSCs forward as a cellular therapy and the challenges along the regulatory pathway when using these cells in research. Panelists: Dr. Keith Wonnacott, US Food and Drug Administration; Dr. Steve Finkbeiner, University of California, San Francisco; Dr. Kyle Kolaja, Cellular Dynamics; Dr. Melissa Carpenter, Carpenter Group Consulting

Recording>>

Microscale Engineering Strategies to Functionally Mature iPSC-derived Human Hepatocytes (Originally aired Sep 18). Discover how iCell Hepatocytes cultured in an engineered micropatterned co-culture platform enhances their functional application in drug metabolism and toxicity assessment. Presenters: Dr. Salman Khetani, Colorado State University; Dr. David Mann, Cellular Dynamics

Recording>>

Using Induced Pluripotent Stem Cells in Drug Discovery (Originally aired Sep 18). Hear case studies from expert panelists as they share perspectives on using iPSCs in drug discovery research. Panelists: Dr. Timothy J. Kamp, University of Wisconsin; Dr. Steve Stice, University of Georgia

Recording>>

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Publications

Integrin-linked Kinase Mediates Force Transduction in Cardiomyocytes by Modulating SERCA2a/PLN Function. Find out how iCell Cardiomyocytes verified potential therapeutic targets in heart disease research.

Traister A, Li M, et al. (2014) Nature Commun 5:4533.

Article>>

RNA Expression Profiling of Human iPSC-derived Cardiomyocytes in a Cardiac Hypertrophy Model. Read how iCell Cardiomyocytes treated to mimic heart disease enabled the identification of unique miRNA and RNA pairs.

Aggarwal P, Turner A, et al. (2014) PLoS One 9(9):e108051.

Article>>

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Conference News

ACEA Biosciences: US xCELLigence Cardio Symposium (Oct 17 – 18 | Arlington, VA). Make sure to attend our podium talk:

  • Arrhythmia and QT Prolongation Prediction Using iCell Cardiomyocytes: Past, Present and Future (Oct 18 | 11:45 am – 12:00 pm)

Details>>

Safety Pharmacology Society Annual Meeting (Oct 19 – 22 | Washington DC | Booth 111). Join us at the following workshop:

  • New Techniques for MEA-based Interrogation of Human Stem Cell Derived Cardiomyocytes to Support CIPA and In-Vitro Safety Pharmacology Assays (Oct 20, 6:00 – 7:00 pm | Room Wilson B)

Details>>

Translating Medical Technologies from the Lab to the Clinic: Challenges and Opportunities (Oct 21 | 4:00 – 6:00 pm | Yale University). Hear from and ask questions of experienced panelists as they discuss translating regenerative medicine technologies into profitable and scalable business models. Panelists: Dr. Laura Niklason, Yale University; Dr. Mei Wei, University of Connecticut; Dr. Christopher Loose, Yale University; Dr. Kyle Kolaja, Cellular Dynamics

Details>>

ChanTest User Meeting: Collaborations in Drug Discovery (Oct 30 – 31 | Boston, MA). Don’t miss this presentation:

  • We’ve Crossed the Chasm and Climbed out of the Trough, Now What? Advances and Advantages with iPSC-derived Cell Types in Drug Discovery (Oct 31 | 10:00 – 10:15 am)

Details>>

Neuroscience 2014 (Nov 15 – 19 | Washington DC | Booth 436). Mark your day planner to visit these posters:

  • Characterization of an Isogenic Disease Model of Alzheimer’s Disease from Human iPS Cell-derived Neurons (Nov 16 | 9:00 – 10:00 am | Poster D70)
  • A New MEA Analysis Tool for Measuring Pharmaco-influences on Human iPS Cell-derived Neurons (Nov 17 | 11:00 am – 12:00 pm | Poster VV20)
  • Axonal Polarity Formation in Human iPSC-derived Neurons (Nov 17 | 3:00 – 4:00 pm | Poster B18)
  • Development and Characterization of Scalable Human Induced Pluripotent Stem Cell-derived Midbrain Dopaminergic Neurons for Drug Discovery and Disease Modeling (Nov 17 | 4:00 – 5:00 pm | Poster B11)
  • Human Neural Microtissues Derived from Induced Pluripotent Stem Cells for Toxicity Testing (Nov 19 | 10:00 – 11:00 am | Poster VV69)
  • Model of Tau Pathology in Induced Pluripotent Stem Cell-derived Human Neurons (Nov 19 | 2:00 – 3:00 pm | Poster C67)
  • Computational Analysis of the Effects of Anti-neoplastic Agents on Intraneuronal Transport of Human iPSC Derived Neurons (Nov 19 | 2:00 – 3:00 pm | Poster VV24)

Details>>

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Applications

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iCell Cardiomyocytes. Use ViaFect Transfection Reagent (Promega) for highly efficient transfection of iCell Cardiomyocytes with minimal toxicity, enabling experiments to be done in a relevant human cellular background.

Details>>

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Presentations/Posters

presentation

Check out the following poster, presented at MipTec 2014, now accessible online:

    • Development and Characterization of Human iPSC-derived Midbrain Dopaminergic Neurons for Drug Discovery

Poster>>

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