Pacing iCell Cardiomyocytes
Foreseeing drug-induced arrhythmia is a critical component of drug development and the FDA is seeking to increase the predictivity of pre-clinical testing strategies via the Comprehensive In Vitro Proarrhythmia Assay (CIPA) initiative.
Research using iCell® Cardiomyocytes and MEA recordings is part of the CIPA initiative as they have proven to be a predictive and economical system for detecting drug-induced arrhythmia. However, while predictive, the interplay of complex electrophysiological interactions of spontaneously beating cardiomyocytes introduces some difficulties for particular mechanistic interpretations. These difficulties can be addressed using AxIS 2.0 Software (Axion Biosystems). This software allows experimental control of cardiomyocyte beat rate, separation of complex effects, and richer interpretation of the data.