News & Events

March 2015

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March 2015

Welcome to our monthly enewsletter, CDI Notebook, focused on keeping you abreast of the latest innovations using CDI’s iCell® and MyCell® products.

In this issue:
Trending
Webinars
Publications
Press
Conference News
Presentations/Posters

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Trending

Trending

CDI Product Teaser! Can you guess what new product coming Mar 23, 2015, will provide these benefits and more?

  • Increases investigator throughput 3-fold
  • Provides project answers within a single work week
  • Makes it easier than ever to implement human biology into drug discovery and toxicity testing

Hint: Its predecessor beats, is highly predictive, has more than 3 dozen publications, and is used by >90% of top pharma.

Answer>>

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Webinars

Using Human Cardiomyocytes in Phenotypic Screens and Target Verification (Mar 31 | Hosted by GEN). Register now to learn about the implementation of phenotypic screens for cardioprotective molecules, potential therapeutic avenues for cardiac hypertrophy, and methods for validating key targets in dilated cardiomyopathy. These endpoints detail the applicability and advantages of utilizing human iPSC-derived cardiomyocytes in drug screening and discovery efforts. Presenters: Anne Bang, PhD, and Siobhan Malany, PhD, Conrad Prebys Center for Chemical Genomics; Jason Thomas Maynes, MD, PhD, Hospital for Sick Children

Register>>

Diabetic Cardiomyopathy Modeling & Screening with iPSC Cardiomyocytes (Apr 7 | Hosted by LabRoots). Sign up today to hear about the development of environmentally and genetically driven in vitro models for diabetic cardiomyopathy using human iPS cell-derived cardiomyocytes and their use in phenotypic screens to identify new potential drug discovery paths. Presenters: Roberto Iacone, PhD, Hoffmann-La Roche; Brad Swanson, PhD, Cellular Dynamics International

Register>>

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Publications

Association of an Inherited Genetic Variant with Vincristine-related Peripheral Neuropathy in Children with Acute Lymphoblastic Leukemia. Discover how researchers identified genetic polymorphisms associated with chemotherapeutic-induced neuropathies in children with acute lymphoblastic leukemia (ALL) through a genome-wide association study (GWAS) and used iCell Neurons to corroborate their clinical findings.

Diouf B, Crews KR, et al. (2015) JAMA.

Article>>

A Beating Heart Cell Model to Predict Cardiotoxicity: Effects of the Dietary Supplement Ingredients Higenamine, Phenylethylamine, Ephedrine and Caffeine. Access this manuscript to learn how investigators at the FDA are using iCell Cardiomyocytes for early determination of the effects that dietary supplements may have on cardiac behavior.

Calvert R, Vohra S, et al. (2015) Food Chem Toxicol.

Article>>

Development and Characterization of a Scaffold-free 3D Spheroid Model of iPSC-derived Human Cardiomyocytes. Learn about the characterization and properties of iCell Cardiomyocytes in a recently developed, easy-to-use 3D model.

Beauchamp P, Moritz W, et al. (2015) Tissue Eng Part C: Methods.

Article>>

Human iPSC-derived Hepatocyte-like Cells Support Plasmodium Liver-stage Infection In Vitro. Read how iCell Hepatocytes support research of malaria infection by P falciparum and P vivax parasites and show the applicability of these human iPS cells in drug discovery.

Ng S, Schwartz RE, et al. (2015) Stem Cell Reports.

Article>>

Prediction of Drug-induced Liver Injury in Micropatterned Co-cultures Containing iPSC-derived Human Hepatocytes. Discover how iCell Hepatocytes demonstrate predictivity and sensitivity in assessing a panel of known hepatotoxins and safe compounds when cultured in a micropatterned co-culture model.

Ware BR, Berger DR, and Khetani SR. (2015) Toxicol Sci.

Article>>

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Press

Could ‘Superdonors’ Make Replacement Organs That Work in Anyone? Read how cells from ‘superdonors’ could enable the generation of replacement organs that won’t be rejected by recipients. A recent Forbes article reports on CDI’s announcement that it is manufacturing cells from two such individuals for possible use in cost-effective cell therapies.

Forbes Article>> | CDI Press Release

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Conference News

receptionSociety of Toxicology Annual Meeting & ToxExpo (Mar 22 – 26 | San Diego, CA | Booth 801). Attend our customer reception and join us at several presentations showcasing the utility of stem cells in toxicity screens including:

  • Toxicological Application of Studies Funded by California Stem Cell Research and Cures Act (Mar 23 | 12:10 – 1:30 pm | Room 1)
  • Cardio-oncology Concerns Encourage Novel Approaches to Pharmaceutical Risk Assessment (Mar 23 | 2:00 – 4:45 pm | Ballroom 6C)
  • Making Cardiotoxicity Prediction Simple and Relevant: Human iPSC-cardiomyocytes and Integrated Impedance- and Field Potential-based Assays Enable Highly Predictive Cardiotoxicity Assessments across Multiple Mechanisms (Mar 24 | 11:30 am – 12:30 pm | Room 24B)

AD/PD 2015 (Mar 18 – 22 | Nice, France | Booth 2A). View these posters during the International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders:

  • Characterization of an Isogenic Disease Model of Alzheimer’s Disease from Human iPS Cell-derived Neurons (Mar 18 | Exhibit Hall, Poster 5-0567)
  • Development and Characterization of Scalable Human Induced Pluripotent Stem Cell-derived Midbrain Dopaminergic Neurons for Drug Discovery and Disease Modeling (Mar 21 | Exhibit Hall, Poster 5-2244)
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Presentations/Posters

Access these posters, presented at Biophysical Society Annual Meeting, online:

  • Automated Patch-clamp Allowing Accurate Recording of Physiological and Drug-induced Cardiac Late Sodium Current
  • Human iPS Cell-derived Cardiomyocytes Carrying MYH7-R403Q Exhibit Aspects of Hypertrophic Cardiomyopathy In Vitro
  • Modeling Neurological Disease with Human iPS Cell-derived Neurons Containing a KCNT1 Mutation

Posters>>

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