Products & Services

iCell® GABANeurons

Advancing New Paradigms in Neuroscience Research

Traditional neuroscience research tools consist largely of rodent primary cell cultures and animal models, which are labor-intensive, costly, and poorly reflective of native human biology. iCell® GABANeurons represent a relevant human in vitro system for modeling and interrogating complex neurological processes and diseases.

iCell GABANeurons are iPS cell-derived mixed populations of human cerebral cortical neurons that exhibit native electrical and biochemical activity. They overcome limitations of existing models by providing the following:

  • >95% pure population of primarily GABAergic (inhibitory) neurons
  • Rapid formation of neural networks and functional synapses
  • Expression of relevant neurological therapeutic targets and pathways
  • Long-term viability and demonstrated reproducibility
  • Reliable supply in cryopreserved format

More Data, More Publications, More Solutions

There is a broad range of peer-reviewed publications and CDI application protocols and applications notes  to support your research goals including:

  • Alzheimer’s disease research and drug discovery
    Functional tau and β-amyloid toxicity pathways, long-term viability, and flexible product format enable high-throughput screening for novel drug candidates
  • Autism disease research
    Demonstrated prefrontal cortex ionotropic glutamate receptors, GABAA receptor, and synaptic functionality drive interrogation of neurological diseases, such as autism
  • Infectious disease studies
    Susceptibility to varicella zoster virus infection and ability to maintain viral latency and reactivation
  • Therapeutic potency testing
    High sensitivity, dose-response, and biological responses to Clostridium botulinum neurotoxin (BoNT) aid replacement of the gold-standard mouse bioassay for BoNT potency testing
  • Neurotoxicity assessment
    Compatibility with a wide range of high-content, high-throughput platforms enables assessment of pharmaceutical and environmental neurotoxicity