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iCell Microglia Alzheimer's Disease Panel

Investigate Microglia Function from an Alzheimer’s Disease Cohort

Microglia, the resident immune cells of the brain, are key players in neuroinflammation and manifestation of neurodegenerative diseases. Recent studies have identified highly expressed genes in microglia that are associated with increased risk of developing Alzheimer’s disease (AD), propelling microglia to the forefront of neurodegenerative disease progression and emphasizing the critical need of model systems to study microglia. The limited availability and inconsistency of primary human microglia has constrained research and therapeutic progress. iCell® Microglia, based on technology developed by the Blurton-Jones laboratory (Abud et al. Neuron 2017) for which FUJIFILM Cellular Dynamics Inc. has an exclusive license from the University of California-Irvine, overcome these constraints by offering consistent, high-quality microglia derived from human induced pluripotent stem cells, thus enabling the study of cytokine signaling, synaptic transmission, and plasticity in normal CNS function and during disease progression.

Recent GWAS studies have shown that genetically inherited variants apolipoprotein E4 (APOE4) and the presence of specific Single Nucleotide Polymorphisms (SNPs) within triggering receptor expressed on myeloid cells 2 (TREM2), CD33 or Siglec 3, ATP-binding cassette transporter A7 (ABCA7), have a strong association with increased disease risk of AD. The AD-associated iCell Microglia panel represents microglia generated from 12 human iPSCs from apparently healthy normal (AHN) and diseased donors harboring many inherited mutations associated with AD.

Figure 1: Genotypes and Donor Phenotypes of iCell Microglia


Figure 2: iCell Microglia Purity
iCell Microglia have a consistently high purity across a group of 12 donors as judged by the presence of cell surface (CD45, CD11b and CD33) and intracellular (P2RY12, TREM-2, CX3CR1, IBA) microglia-specific antigens.

 

 

Figure 3: iCell Microglia Phagocytosis Kinetics
Microglia from different disease panel donors display unique kinetics of phagocytosis of pHrodo-labelled amyloid beta.

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    Catalog # Description Quantity Price
    R1209 iCell Microglia Kit, AD, APOE E2/E4, 11968

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1223 Cryopreserved iCell Microglia APOE E2/E4, 11968
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1223 iCell Microglia, AD, APOE E2/E4, 11968

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1223 Cryopreserved iCell Microglia 11968
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1213 iCell Microglia Kit, AD APOE E4/E4, 11995

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1227 Cryopreserved iCell Microglia AD, APOE E4/E4, 11995
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1227 iCell Microglia, AD, APOE E4/E4, 11995

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1227 Cryopreserved iCell Microglia 11995
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1215 iCell Microglia Kit, AD APOE E4/E4, 12061

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1229 Cryopreserved iCell Microglia AD, APOE E4/E4, 12061
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1229 iCell Microglia, AD, APOE E4/E4, 12061

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1229 Cryopreserved iCell Microglia 12061
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1214 iCell Microglia Kit, AD APOE E4/E4, 12037

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1228 Cryopreserved iCell Microglia AD, APOE E4/E4, 12037
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1228 iCell Microglia, AD, APOE E4/E4, 12037

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1228 Cryopreserved iCell Microglia 12037
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1212 iCell Microglia Kit, AD APOE E4/E4, 11993

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1226 Cryopreserved iCell Microglia AD  APOE E4/E4, 11993
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1226 iCell Microglia, AD, APOE E4/E4, 11993

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1226 Cryopreserved iCell Microglia 11993
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1216 iCell Microglia Kit, AHN, ABCA7 G1527A, 12000

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1230 Cryopreserved iCell Microglia AHN ABCA7 G1527A, 12000
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1230 iCell Microglia, AHN, ABCA7 G1527A, 12000

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1230 Cryopreserved iCell Microglia 12000
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1217 iCell Microglia Kit, AHN, TREM2 R47H, 11969

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1231 Cryopreserved iCell Microglia AHN, TREM2 R47H, 11969
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1231 iCell Microglia, AHN, TREM2 R47H, 11969

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1231 Cryopreserved iCell Microglia 11969
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1211 iCell Microglia Kit, AHN CD33, 12005

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1225 Cryopreserved iCell Microglia AHN CD33, 12005
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1225 iCell Microglia, AHN CD33, 12005

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1225 Cryopreserved iCell Microglia 12005
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1206 iCell Microglia Kit, AHN, 12023

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1220 Cryopreserved iCell Microglia AHN, 12023
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1220 iCell Microglia, AHN, 12023

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1220 Cryopreserved iCell Microglia 12023
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1207 iCell Microglia Kit, AHN, 12056

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1221 Cryopreserved iCell Microglia AHN, 12056
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1221 iCell Microglia, AHN, 12056

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1221 Cryopreserved iCell Microglia 12056
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1208 iCell Microglia Kit, AHN, 12068

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1222 Cryopreserved iCell Microglia AHN, 12068
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1222 iCell Microglia, AHN, 12068

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1222 Cryopreserved iCell Microglia 12068
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability
    R1210 iCell Microglia Kit, AHN, 12024

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1224 Cryopreserved iCell Microglia AHN, 12024
    • M1034 50ml iCell Glial Base Medium
    • M1036 0.5ml iCell Microglia Supplement A (100x)
    • M1037 0.5ml iCell Microglia Supplement B (100x)
    • M1035 2 x 1ml iCell Neural Supplement C (25X)
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $2275
    Inquire About Pricing & Availability
    C1224 iCell Microglia, AHN, 12024

    Please contact our customer support team to inquire about availability.

    Each kit contains:

    • C1224 Cryopreserved iCell Microglia 12024
    • X1022 iCell Microglia Quick Guide
    • Additional reagents required; see Quick Guide
    ≥1 x 106
    Viable Cells/Vial
    $1975
    Inquire About Pricing & Availability