Revitalize Your Phenotypic Screens with iPSC Technology
Induced pluripotent stem cell (iPSC) technology, fueled by Cellular Dynamics’ iCell® and MyCell® products, affords unprecedented access to biologically relevant human in vitro cell models for disease modeling, drug discovery, and phenotypic screening as well as safety assessment. The ability to model disease with iPSC-derived tissues can be envisioned to encompass innate, engineered and induced phenotypes generated in vitro:
- Innate models are derived from iPSC reprogrammed from a diseased donor population and manifest the inherent genetically predisposed condition.
- Engineered models are produced by making specific genetic edits to input or correct a disease relevant specific polymorphism.
- Induced models are developed by exposing the cells to disease phenotype causative culture conditions (e.g. media formulations, pathway modulators, or infectious agents) to elicit the phenotype.
Disease Modeling Approaches with iPSCs
iPSC technology offers reliable and predictive model systems not attainable with cancer lines, primary cells or immortalized cells, thereby creating new tools and opportunities in drug discovery. In many cases iPSC-derived tissues, such as iCell and MyCell cardiac and neural cells, represent sources of previously unattainable human cells available in unlimited quantities in high purity and free of donor variability complications. CDI’s current efforts include generating large iPSC clone banks from multiple varied disease backgrounds to expand access to previously unavailable cell models for discovery.
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- Cell Press Article:
Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy Using Human Induced Pluripotent Stem Cells
Researchers detail the recapitulation of cardiomyopathy through environmental and genetic mechanisms and establish the utility of phenotypic screens to find molecules and pathways that may provide a therapeutic option.
- Biophysical Society 2015 Presentation:
Modeling Neurological Disease with Human iPS Cell-derived Neurons Containing a KCNT1 Mutation
iPSC-derived neurons carrying the familial epilepsy mutation KCNT1 P924L show a gain-of-function autosomal dominant phenotype, providing a model-in-a-dish for studying this disease.