Thank You for Your Interest in Phenotypic Screening
Please click the links to access the case studies:
- Cell Press Article:
Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy Using Human Induced Pluripotent Stem Cells
Researchers detail the recapitulation of cardiomyopathy through environmental and genetic mechanisms and establish the utility of phenotypic screens to find molecules and pathways that may provide a therapeutic option.
- Biophysical Society 2015 Presentation:
Modeling Neurological Disease with Human iPS Cell-derived Neurons Containing a KCNT1 Mutation
iPSC-derived neurons carrying the familial epilepsy mutation KCNT1 P924L show a gain-of-function autosomal dominant phenotype, providing a model-in-a-dish for studying this disease.