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November 2014

Caralt M, Uzarski JS, Iacob S, Obergfell KP, Berg N, Bijonowski BM, Kiefer KM, Ward HH, Wandinger-Ness A, Miller WM, Zhang ZJ, Abecassis MM, and Wertheim JA

Optimization and Critical Evaluation of Decellularization Strategies to Develop Renal Extracellular Matrix Scaffolds As Biological Templates for Organ Engineering and Transplantation

Am J Transplant 15(1):64-75

Publication Date: November 17, 2014

Product Type: iCell Endothelial Cells

Summary:

iCell Endothelial Cells were used to reform the vasculature in a decellularized rat kidney. The cells were fluorescently tagged to enable visualization of the vascular network.

Impact:

This research is a milestone in the advancement of generating transplantable tissue, either autologous or allogeneic.

September 2014

Belair DG, Whisler JA, Valdez J, Velazquez J, Molenda JA, Vickerman V, Lewis R, Daigh C, Hansen TD, Mann DA, Thomson JA, Griffith LG, Kamm RD, Schwartz MP, and Murphy WL

Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells

Stem Cell Rev [Epub ahead of print]

Publication Date: September 5, 2014

Product Type: iCell Endothelial Cells

Summary:

iCell Endothelial Cells were cultured within several bioengineered platforms mimicking the in vivo microenvironment and formed vascular architecture to enable tissue engineering and discovery applications. Assays for measuring migration, invasion, and vascular sprouting in response to cytokines and inhibitors are also reported along with basic characterization data.

Impact:

This is the first iCell Endothelial Cells publication to illustrate multiple applications in bioengineering, vascular network formation, and angiogenesis for regenerative medicine, tissue engineering, toxicity, and discovery applications.

February 2014

Gui L and Niklason LE

Vascular Tissue Engineering: Building Perfusable Vasculature for Implantation

Curr Opin Chem Eng 3:68-74

Publication Date: February 7, 2014

Product Type: iCell Endothelial Cells

Summary:

A review article describing the state of the art for vascular biology in generating perfusable tissues for therapeutic applications. The potential for iPSC-derived endothelial cells (ECs) in such applications is reported.

Impact:

iCell Endothelial Cells are currently commercially available as iCell Endothelial Cells (Cellular Dynamics International). As such, human iPSCs offer the advantages of providing a possibly unlimited number of autologous ECs to vascularize tissue engineered constructs for implantation.