Cohen JD, Babiarz JE, Abrams RM, Guo L, Kameoka S, Chiao E, Taunton J, and Kolaja KL
Toxicol Appl Pharmacol 257(1):74-83
Publication Date: August 27, 2011
Product Type: iCell Cardiomyocytes
Elucidation of the molecular mechanisms of sunitinib-induced cardiotoxicity using iCell Cardiomyocytes revealed, contrary to previous data using rodent models, that AMPK and RSK do not play a significant role.
This study illustrates the limitations of non-human model systems and the benefit and importance of using a human cell-based model system to detect and study human cardiotoxicity.