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September 2011

Dias J, Gumenyuk M, Kang H, Vodyanik M, Yu J, Thomson JA, and Slukvin II

Generation of Red Blood Cells from Human Induced Pluripotent Stem Cells

Stem Cells Dev 20(9):1639-47

Publication Date: September 20, 2011

Product Type: CDI Technology, iCell Products

Summary:

Description of an approach for the efficient generation of RBCs from hiPSC/hESCs using an OP9 co-culture system to induce hematopoietic differentiation followed by selective expansion of erythroid cells in serum-free media with erythropoiesis-supporting cytokines.

Ma J, Guo L, Fiene SJ, Anson BD, Thomson JA, Kamp TJ, Kolaja KL, Swanson BJ, and January CT

High Purity Human-induced Pluripotent Stem Cell-derived Cardiomyocytes: Electrophysiological Properties of Action Potentials and Ionic Currents

Am J Physiol Heart Circ Physiol 301(5):H2006-17

Publication Date: September 2, 2011

Product Type: iCell Cardiomyocytes

Summary:

This comprehensive characterization study demonstrated that iCell Cardiomyocytes display cellular electrophysiological properties similar to native human cardiomyocytes.

Impact:

iCell Cardiomyocytes exhibit electrophysiological characteristics similar to native human cardiomyocytes and thus provide a relevant in vitro model for disease modeling, drug discovery, and toxicity testing.