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January 2012

Whitemarsh RC, Strathman MJ, Chase LG, Stankewicz C, Tepp WH, Johnson EA, and Pellett S

Novel Application of Human Neurons Derived from Induced Pluripotent Stem Cells for Highly Sensitive Botulinum Neurotoxin Detection

Toxicol Sci 126(2):426-35

Publication Date: January 5, 2012

Product Type: iCell GABANeurons

Summary:

iCell Neurons were identified as a functionally relevant human model to detect and study Clostridium botulinum neurotoxin (BoNT). Compared with primary rat spinal cord cells, iCell Neurons showed equal or increased sensitivity, improved dose-response, and more complete SNARE protein cleavage in response to BoNT treatment.

Impact:

iCell Neurons are rapidly being adopted by academic researchers to study mechanisms of BoNT toxicity, as well as by BoNT manufacturers to detect and measure BoNT potency.