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May 2012

Lee P, Klos M, Bollensdorff C, Hou L, Ewart P, Kamp TJ, Zhang J, Bizy A, Guerrero-Serna G, Kohl P, Jalife J, and Herron TJ

Simultaneous Voltage and Calcium Mapping of Genetically Purified Human Induced Pluripotent Stem Cell-derived Cardiac Myocyte Monolayers

Circ Res 110(12):1556-63

Publication Date: May 8, 2012

Product Type: iCell Cardiomyocytes

Summary:

iCell Cardiomyocytes were used to study mechanisms of cardiac arrhythmia using a multiparametric imaging system that simultaneously measures action potential and intracellular calcium wave propagation.

Impact:

This study demonstrated that iCell Cardiomyocytes can be used in a novel high-throughput assay system to assess drug effects on cardiac arrhythmias. Data showed that iCell Cardiomyocytes offer advantages over commonly used rodent models.