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June 2012

Rana P, Anson B, Engle S, and Will Y

Characterization of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening

Toxicol Sci 130(1):117-31

Publication Date: June 27, 2012

Product Type: iCell Cardiomyocytes

Summary:

Analysis of iCell Cardiomyocytes bioenergetics function revealed that iCell Cardiomyocytes can utilize a variety of energy substrates and exhibit expected responses to known mitochondrial toxicants.

Impact:

iCell Cardiomyocytes were shown to exhibit appropriate bioenergetics functions and can be used to detect mitochondrial dysfunction, which is an important mechanism of drug-induced cardiotoxicity.

Zhi D, Irvin MR, Gu CC, Stoddard AJ, Lorier R, Matter A, Rao DC, Srinivasasainagendra V, Tiwari HK, Turner A, Broeckel U, and Arnett DK

Whole-exome Sequencing and an iPSC-derived Cardiomyocyte Model Provides a Powerful Platform for Gene Discovery in Left Ventricular Hypertrophy

Front Genet 3:92

Publication Date: June 2, 2012

Product Type: iCell Cardiomyocytes

Summary:

iCell Cardiomyocytes were used to develop a functional cellular model of left ventricular hypertrophy (LVH), which enabled the identification of novel disease-associated genetic polymorphisms from a donor population.

Impact:

iCell Cardiomyocytes were used to develop an in vitro cellular model that exhibits functional characteristics of the human cardiac disease LVH. This model was used to identify novel genetic markers associated with the disease.