Resources

Publications

 

 

Show All

June 2012

Chai X, Dage JL, and Citron M

Constitutive Secretion of Tau Protein by an Unconventional Mechanism

Neurobiol Dis 48(3):356-66

Publication Date: June 2, 2012

Product Type: iCell GABANeurons

Summary:

This study was designed to elucidate the mechanism(s) of tau processing and cellular trafficking, the dysregulation of which is a hallmark of Alzheimer’s disease and other tauopathies. iCell Neurons were shown to release a small percentage of intracellular tau by a nonconventional pathway that correlates with tau levels observed in vivo.

Impact:

iCell Neurons provided a biologically relevant human cell model to study the protein tau, which plays an important role in the development of Alzheimer’s disease and other neurodegenerative disorders. iCell Neurons provided significant advantages over other available model systems including transformed cell lines and primary neurons in intact animals.