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June 2013

Fine M, Lu FM, Lin MJ, Moe O, Wang HR, and Hilgemann DW

Human Induced Pluripotent Stem Cell-derived Cardiomyocytes for Studies of Cardiac Ion Transporters

Am J Physiol Cell Physiol 305(5):C481-91

Publication Date: June 26, 2013

Product Type: iCell Cardiomyocytes

Summary:

iCell Cardiomyocytes were analyzed for cardiac ion transporter function. Data demonstrate that iCell Cardiomyocytes exhibit human adult-like expression of major cardiac ion transporters, are amenable to long-term molecular manipulation of individual transporter and regulatory proteins, and can be used for analysis of transporter and regulatory protein turnover.

Impact:

Data support the use of iCell Cardiomyocytes for a wide range of new cellular and molecular experimentation that was previously not possible to elucidate the molecular function and regulation of ion transporters.

Grose C, Yu X, Cohrs RJ, Carpenter JE, Bowlin JL, and Gilden D

Aberrant Virion Assembly and Limited Glycoprotein C Production in Varicella-Zoster Virus-infected Neurons

J Virol 87(17):9643-8

Publication Date: June 26, 2013

Product Type: iCell GABANeurons

Summary:

An iCell Neurons in vitro model of varicella zoster virus (VZV) infection developed by Yu, et al. (2013) was used in a subsequent study to determine whether diminished production of virion components and/or final assembly of complete virions play a role in limiting productive virus infection.

Impact:

Primary VZV infection typically produces varicella (chickenpox), after which the virus becomes latent. Reactivation of the virus produces zoster (shingles), which is a more serious disease characterized by chronic pain and other neurological problems. iCell Neurons are used to model VZV infection and better define the molecular underpinnings of the virus-host relationship.