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June 2013

Fine M, Lu FM, Lin MJ, Moe O, Wang HR, and Hilgemann DW

Human Induced Pluripotent Stem Cell-derived Cardiomyocytes for Studies of Cardiac Ion Transporters

Am J Physiol Cell Physiol 305(5):C481-91

Publication Date: June 26, 2013

Product Type: iCell Cardiomyocytes

Summary:

iCell Cardiomyocytes were analyzed for cardiac ion transporter function. Data demonstrate that iCell Cardiomyocytes exhibit human adult-like expression of major cardiac ion transporters, are amenable to long-term molecular manipulation of individual transporter and regulatory proteins, and can be used for analysis of transporter and regulatory protein turnover.

Impact:

Data support the use of iCell Cardiomyocytes for a wide range of new cellular and molecular experimentation that was previously not possible to elucidate the molecular function and regulation of ion transporters.