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July 2013

Ivashchenko CY, Pipes GC, Lozinskaya IM, Lin Z, Xiaoping X, Needle S, Grygielko ET, Hu E, Toomey JR, Lepore JJ, and Willette RN

Human-induced Pluriopotent Stem Cell-derived Cardiomyocytes Exhibit Temporal Changes in Phenotype

Am J Physiol Heart Circ Physiol 305(6):H913-22

Publication Date: July 5, 2013

Product Type: iCell Cardiomyocytes

Summary:

In culture, iCell Cardiomyocytes progressively develop a more mature phenotype without signs of dedifferentiation. This phenotype is characterized by adult-like gene expression patterns, action potentials exhibiting ventricular atrial and nodal properties, coordinated calcium cycling and mechanical activity with pharmacological responses to pathologic (ET-1), physiologic (IGF-1) and autonomic (isoproterenol) stimuli similar to those characteristic of isolated adult cardiac myocytes.

Impact:

This study demonstrates that iCell Cardiomyocytes recapitulate native tissue characteristics.