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September 2013

Carlson C, Koonce C, Aoyama N, Einhorn S, Fiene S, Thompson A, Swanson B, Anson B, and Kattman S

Phenotypic Screening with Human iPS Cell-derived Cardiomyocytes: HTS-compatible Assays for Interrogating Cardiac Hypertrophy

J Biomol Screen 18(10):1203-11

Publication Date: September 26, 2013

Product Type: iCell Cardiomyocytes

Summary:

High-throughput protein-based assays were developed with iCell Cardiomyocytes as a system to induce and ameliorate hypertrophy.

Impact:

This research demonstrates the practicality and utility of utilizing relevant native human biology in disease modeling and high-throughput screens for drug discovery.

Guo L, Coyle L, Abrams RM, Kemper R, Chiao ET, and Kolaja KL

Refining the Human iPSC-cardiomyocyte Arrhythmic Risk Assessment Model

Toxicol Sci 136(2):581-94

Publication Date: September 19, 2013

Product Type: iCell Cardiomyocytes

Summary:

iCell Cardiomyocytes were able to predict QT prolongation and arrhythmia with greater accuracy than current in vitro models when challenged with a set of 118 public and proprietary compounds.

Impact:

This study demonstrates that iCell Cardiomyocytes provide improved proarrhythmia predictions on a higher throughput screening platform thus providing value-added data with fewer resources.