Publications
Carlson C, Koonce C, Aoyama N, Einhorn S, Fiene S, Thompson A, Swanson B, Anson B, and Kattman S
J Biomol Screen 18(10):1203-11
Publication Date: September 26, 2013
Product Type: iCell Cardiomyocytes
Summary:
High-throughput protein-based assays were developed with iCell Cardiomyocytes as a system to induce and ameliorate hypertrophy.
Impact:
This research demonstrates the practicality and utility of utilizing relevant native human biology in disease modeling and high-throughput screens for drug discovery.
Guo L, Coyle L, Abrams RM, Kemper R, Chiao ET, and Kolaja KL
Refining the Human iPSC-cardiomyocyte Arrhythmic Risk Assessment Model
Toxicol Sci 136(2):581-94
Publication Date: September 19, 2013
Product Type: iCell Cardiomyocytes
Summary:
iCell Cardiomyocytes were able to predict QT prolongation and arrhythmia with greater accuracy than current in vitro models when challenged with a set of 118 public and proprietary compounds.
Impact:
This study demonstrates that iCell Cardiomyocytes provide improved proarrhythmia predictions on a higher throughput screening platform thus providing value-added data with fewer resources.