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April 2014

Nakamura Y, Matsuo J, Miyamoto N, Ojima A, Ando K, Kanda Y, Sawada K, Sugiyama A, and Sekino Y

Assessment of Testing Methods for Drug-induced Repolarization Delay and Arrhythmias in an iPS Cell–derived Cardiomyocyte Sheet: Multi-site Validation Study

J Pharmacol Sci 124(4):494-501

Publication Date: April 2, 2014

Product Type: iCell Cardiomyocytes

Summary:

The experimental robustness of iCell Cardiomyocytes was tested across three independent laboratories. hERG channel (IKr) block was assessed via MEA-measured field potential duration prolongation in each laboratory and found to be equivalent.

Impact:

These data demonstrate that iCell Cardiomyocytes utilized in standardized protocols provide inter-facility robustness and repeatability.