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September 2014

Belair DG, Whisler JA, Valdez J, Velazquez J, Molenda JA, Vickerman V, Lewis R, Daigh C, Hansen TD, Mann DA, Thomson JA, Griffith LG, Kamm RD, Schwartz MP, and Murphy WL

Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells

Stem Cell Rev [Epub ahead of print]

Publication Date: September 5, 2014

Product Type: iCell Endothelial Cells

Summary:

iCell Endothelial Cells were cultured within several bioengineered platforms mimicking the in vivo microenvironment and formed vascular architecture to enable tissue engineering and discovery applications. Assays for measuring migration, invasion, and vascular sprouting in response to cytokines and inhibitors are also reported along with basic characterization data.

Impact:

This is the first iCell Endothelial Cells publication to illustrate multiple applications in bioengineering, vascular network formation, and angiogenesis for regenerative medicine, tissue engineering, toxicity, and discovery applications.