Rajesh D, Dickerson SJ, Yu J, Brown ME, Thomson JA, and Seay NJ
Publication Date: July 27, 2011
Product Type: CDI Technology
Generation of iPSCs from two LCLs via a feeder-free episomal method using a cocktail of transcription factors and small molecules. LCL-derived iPSCs exhibited normal karyotype, expressed pluripotency markers, lost oriP/EBNA-1 episomal vectors, generated teratomas, retained donor identity and differentiated in vitro into hematopoietic, cardiac, neural, and hepatocyte-like lineages.