Publications

Summary:

Cellular alignment, sarcomeric organization, and Ca²⁺ cycling properties were altered when iCell Cardiomyocytes were cultured on a structured substrate.

Impact:

This manuscript is an example of the value in combining advanced cell culture techniques with advanced cellular biology can create a more robust recapitulation of native cellular behavior.

Summary:

Cardiac hypertrophy was induced in iCell Cardiomyocytes through low-density plating. The hypertrophic condition resulted in larger cardiomyocytes and altered gene and protein expression profiles.

Impact:

This body of work demonstrates that iCell Cardiomyocytes can be induced to show relevant and appropriate pathological responses and provide utility as an in vitro model for understanding and treating cardiac disease.