Publications
Biomaterials 34(10):2399-411
Publication Date: December 20, 2013
Product Type: iCell Cardiomyocytes
Summary:
Cellular alignment, sarcomeric organization, and Ca2+ cycling properties were altered when iCell Cardiomyocytes were cultured on a structured substrate.
Impact:
This manuscript is an example of the value in combining advanced cell culture techniques with advanced cellular biology can create a more robust recapitulation of native cellular behavior.
J Pharmacol Toxicol Methods 69(2):177-88
Publication Date: December 1, 2013
Product Type: iCell Cardiomyocytes
Summary:
Cardiac hypertrophy was induced in iCell Cardiomyocytes through low-density plating. The hypertrophic condition resulted in larger cardiomyocytes and altered gene and protein expression profiles.
Impact:
This body of work demonstrates that iCell Cardiomyocytes can be induced to show relevant and appropriate pathological responses and provide utility as an in vitro model for understanding and treating cardiac disease.