Alhebshi AH, Odawara A, Gotoh M, and Suzuki I
Neurosci Lett 570:126-31
Publication Date: June 6, 2014
Product Type: iCell GABANeurons
Synapse density, synaptic vesicle recycling and electrical activity were assessed in iCell Neurons before and after treatment with α-synuclein and thymoquinone (TQ). iCell Neurons exhibited toxicity to α-synuclein, which was reduced upon treatment with TQ.
Neuroprotection against synapse damage associated with Parkinson’s disease was demonstrated in iCell Neurons, providing evidence that these cells are a relevant system to discover potential therapeutics for neurodegenerative diseases.