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November 2011

Mack AA, Kroboth S, Rajesh D, and Wang WB

Generation of Induced Pluripotent Stem Cells from CD34+ Cells across Blood Drawn from Multiple Donors with Non-integrating Episomal Vectors

PLoS One 6(11):e27956

Publication Date: November 22, 2011

Product Type: CDI Technology, iCell Products

Summary:

Demonstration of reprogramming from a single vial of blood or less using cells expressing the early lineage marker CD34 as well as from unpurified peripheral blood mononuclear cells.

Impact:

The methodology described demonstrates the creation of induced pluripotent stem cells from blood samples without the use of integrating reprogramming vectors, avoiding modifications of the donor genome while utilizing the least invasive sampling methodology.

Jonsson MK, Wang QD, and Becker B

Impedance-based Detection of Beating Rhythm and Proarrhythmic Effects of Compounds on Stem Cell-derived Cardiomyocytes

Assay Drug Dev Technol 9(6):589-99

Publication Date: November 15, 2011

Product Type: iCell Cardiomyocytes

Summary:

A series of reference compounds were used to demonstrate the use of iCell Cardiomyocytes with the xCELLigence RTCA Cardio System to detect compound effects on cardiac beat frequency and arrhythmias over an assay period of several days.

Impact:

iCell Cardiomyocytes exhibit electrophysiological characteristics similar to native human cardiomyocytes and showed appropriate response to known toxic drug compounds using a cell analysis platform commonly used in the pharmaceutical industry.