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July 2011

Rajesh D, Dickerson SJ, Yu J, Brown ME, Thomson JA, and Seay NJ

Human Lymphoblastoid B Cell Lines Reprogrammed to EBV-free Induced Pluripotent Stem Cells

Blood 118(7):1797-1800

Publication Date: July 27, 2011

Product Type: CDI Technology


Generation of iPSCs from two LCLs via a feeder-free episomal method using a cocktail of transcription factors and small molecules. LCL-derived iPSCs exhibited normal karyotype, expressed pluripotency markers, lost oriP/EBNA-1 episomal vectors, generated teratomas, retained donor identity and differentiated in vitro into hematopoietic, cardiac, neural, and hepatocyte-like lineages.