Toxicol Sci 126(2):426-35
Publication Date: January 5, 2012
Product Type: iCell GABANeurons
iCell Neurons were identified as a functionally relevant human model to detect and study Clostridium botulinum neurotoxin (BoNT). Compared with primary rat spinal cord cells, iCell Neurons showed equal or increased sensitivity, improved dose-response, and more complete SNARE protein cleavage in response to BoNT treatment.
iCell Neurons are rapidly being adopted by academic researchers to study mechanisms of BoNT toxicity, as well as by BoNT manufacturers to detect and measure BoNT potency.
Stem Cells Dev 21(11):1956-65
Publication Date: January 4, 2012
Product Type: iCell Cardiomyocytes
iCell Cardiomyocytes mRNA and miRNA transcriptomes were analyzed at various time-points during and post-differentiation and compared to primary cardiac tissue biopsied from human fetal, adult normal and hypertensive hearts.
This study demonstrated that iCell Cardiomyocytes exhibit developmental markers similar to native human cardiac tissue and maintain a stable cardiac cell phenotype for several months in culture. Data support the use of iCell Cardiomyocytes as a relevant human model system for both acute and chronic studies of cardiac cell function.