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April 2012

Phillips MJ, Wallace KA, Dickerson SJ, Miller MJ, Verhoeven AD, Martin JM, Wright LS, Shen W, Capowski EE, Percin EF, Perez ET, Zhong X, Canto-Soler MV, and Gamm DM

Blood-derived Human iPS Cells Generate Optic Vesicle-like Structures with the Capacity to Form Retinal Laminae and Develop Synapses

Invest Ophthalmol Vis Sci 53(4):2007-19

Publication Date: April 18, 2012

Product Type: iCell GABANeurons,

Summary:

MyCell iPS Cells were used to generate optical vesicle-like structures that have the capacity to self-assemble into rudimentary neuroretinal structures that express markers indicative of chemical and electrical synapses.

Impact:

MyCell iPS Cells were differentiated into retinal cell types and structures that can be used for disease modeling and early investigational studies toward the application of iPS cells for future regenerative medicine applications.